A seizure is an overexcitable state of nerve cells in  
the brain, sometimes leading to sudden, violent, 
involuntary contractions of a group of muscles 
and/or manifestations of decreased awareness of 
environmental surroundings (e.g., blank stare with 
repetitive blinking). 
A contraction is shortening and thickening of the 
muscles. Seizures can occur in distinct predictable 
episodes (as in a chronic seizure disorder) 
independent of external events or they can occur 
suddenly in response to an external event such as a 
traumatic brain injury.
 
During a seizure, nerve cells 
(gray) fire electric impulses too 
rapidly and frequently (red). 
 
Seizures are sometimes described as focal, which means that they originate from a 
specific region of the brain. Seizures are sometimes described as unilateral or bilateral, 
meaning that they can originate from one or both sides of the brain, respectively. 
Seizures are sometimes described as partial, which also means that they come from one 
area of the brain. 
If seizures are described as generalized, this means that the disruption of nerve cells 
spread from one brain region to multiple brain regions on both sides. Some seizures are 
described as tonic, meaning that the muscles (usually the limbs) are extended and stiff. 
 
Others seizures are described as clonic, meaning 
that the muscles are jerking back and forth. When 
tonic and clonic seizures occur together they are 
known as tonic-clonic seizures. 
The word "seizure" is sometimes use as a general 
term to describe an attack, the sudden onset of a 
disease, or the sudden onset of certain 
symptoms. Recurrent episodes of seizures are  
typically referred to as epilepsy. A seizure is also 
known as a convulsion. Seizure comes from the 
Old French word "seisir" meaning "to grasp."